#5111 HEMODIALYSIS TUNNELED CATHETERS LOCK WITH TAUROLOCK™ VERSUS A COMBINATION OF GENTAMYCINE AND HEPARINE

Abstract Background and Aims Catheter-associated infections (CAIs) thrombosis (CAT) are the most common complications, associated with use of tunneled catheters for hemodialysis. The incidence is about 1.8-6.5/1000 catheter-days, thromboses main cause catheter dysfunction loss vascular access in 30-40% patients. aim our study was to determine these complications patients whom we used prophylactic “locking” their catheters. Method included signed an Informed Consent (№29.06.2021) approved by Research Ethics Committee at MU-Pleven. conducted period 01.10.2021 - 31.03.2022, a total six months. 23 men 22 women average age 60.82 (+/-13,629) years, difference between three groups can be considered insignificant (P = .046). All had placed >3 months ago (mean duration 714 +/- 247 catheter-days) as only hemodialysis treatment. After clinical examination negative result two blood cultures, were randomly divided into 15 (fifteen) people each, 45 (forty-five) participants: group A – locking TauroLock™ (Tauropharm, Waldbüttelbrunn, Germany), B gentamicin (10 mg/ml) heparin (1250 IU/ml) C months, then next study. Patients monitored major catheter-related infection (CRI) (CRT). data statistically processed Statgraphics 19. Results median 8,105 catheter-days (CD). One complication reported each groups: one case CRI, CRT each. No cases catheter-associated bloodstream infection, requiring prolonged treatment thrombosis, replacement reported. Reported costs treated calculated 3 EUR/each dialysis session, 0.88 EUR/dialysis session. Conclusion from unequivocally support thesis that solution containing comparable effect antibiotic anticoagulant. In short term, price medicines significant, but it does not exceed potential losses public funds medium long term. We recommend similar regimen all possible or expected greater than ninety days.